Adverse reactions are seen in up to 20% of patients who receive IVIG. These include:

Phlogistic

  • Chills
  • Fever
  • Nausea
  • Vomiting
  • Flushing
  • Myalgias
  • Malaise
  • Headache

Anaphylactoid

  • Nausea
  • Vomiting
  • Flushing
  • Tachycardia
  • Urticaria
  • Eczematous dermatitis
  • Chest tightness or dyspnea
  • Pain in the chest or lower back
  • Sense of impending doom or sudden anxiety
  • Anaphylaxis in IgA deficient patients (X-linked (Bruton’s) agammaglobulinemia)

Thromboembolism

  • Transient ischemic attack and stroke
  • Acute coronary syndrome
  • Myocardial infarctions
  • Deep vein thrombosis
  • Pulmonary emboli

Other

  • Headache
  • Hemolysis
  • Neutropenia
  • Hyponatremia
  • Aseptic meningitis
  • Acute kidney injury
  • Pseudohyponatremia